Sadegh GhaderiNeuroimaging · Neuroinformatics

Projects

Research questions, methods, and outputs.

Projects are structured from the current project page, linked CV, ethics records, related publications, and the research description on the home page. Missing source details are shown explicitly rather than inferred.

OngoingFebruary 2026 – Present

Current Postdoctoral Research in Neuroimaging and Neuroinformatics

Research question

Early diagnosis and PM in Parkinson’s disease and other neurodegenerative conditions.

Methods & techniques

  • 7-Tesla MRI
  • High-resolution quantitative imaging
  • Generative computational models
  • Multimodal integration of imaging, omics, and clinical phenotypes
  • Artificial intelligence and mechanistic modeling
  • Atlas-based analysis of subcortical nuclei

Role

Postdoctoral Fellow in the Neuroinformatics for Personalized Medicine Lab at The Neuro and McConnell Brain Imaging Centre, McGill University.

Outcomes

  • [Ongoing.]

Related links

The Neuro
Completed2019 – 2024

PhD Dissertation — Evaluation of Structural and Functional Brain Changes in Amyotrophic Lateral Sclerosis

Research question

Evaluation of structural and functional brain changes in ALS to identify disease biomarkers and support targeted treatment.

Methods & techniques

  • Multimodal MRI framework
  • Quantitative susceptibility mapping
  • Structural volumetry
  • Diffusion MRI
  • Magnetic resonance spectroscopy
  • Resting-state functional MRI
  • Longitudinal neuroimaging and neuropsychological assessment

Role

PhD researcher at Tehran University of Medical Sciences.

Outcomes

  • Student Innovation Award 2025, International Alliance of ALS/MND Associations
  • Best Thesis Content Award 2024
  • Oral presentation at the 36th International Symposium on ALS/MND
  • Oral presentation at the 14th NiSALS Annual Meeting
  • Digital poster at the 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 related publications
  1. Functional adaptive longitudinal reorganization of superior parietal lobule networks in amyotrophic lateral sclerosis: Evidence suggesting compensatory mechanisms2026 · Brain Research Bulletin
  2. Pathological Aging of Patients With Amyotrophic Lateral Sclerosis: A Preliminary Longitudinal Study2025 · Brain and Behavior
  3. Involvement of the left uncinate fasciculus in the amyotrophic lateral sclerosis: an exploratory longitudinal multi-modal neuroimaging and neuropsychological study2024 · Brain Structure and Function
  4. Metabolite alterations in the left dorsolateral prefrontal cortex and its association with cognitive assessments in amyotrophic lateral sclerosis: A longitudinal magnetic resonance spectroscopy study2024 · Brain Research Bulletin
  5. Quantitative susceptibility mapping in amyotrophic lateral sclerosis: automatic quantification of the magnetic susceptibility in the subcortical nuclei2025 · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
  6. Volume loss in the left anterior‐superior subunit of the hypothalamus in amyotrophic lateral sclerosis2024 · CNS Neuroscience & Therapeutics
  7. A 65‐year‐old woman with ALS and bilateral precentral motor band sign2024 · Clinical Case Reports
  8. Iron quantification in basal ganglia using quantitative susceptibility mapping in a patient with ALS: a case report and literature review2023 · Frontiers in Neuroscience
  9. MRI biomarkers for memory-related impairment in amyotrophic lateral sclerosis: a systematic review2023 · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
Completed2016 – 2019

MSc Thesis — MRI Properties of a Gadolinium-Loaded Aluminosilicate Nanocomposite

Research question

Magnetic resonance imaging characterization of a gadolinium (III)-loaded aluminosilicate nanocomposite containing doxorubicin with a folic acid coating.

Methods & techniques

  • MRI characterization
  • Nanocomposite imaging
  • Image processing
  • Fractal dimension feature extraction and morphological analysis

Role

MSc researcher at Tabriz University of Medical Sciences.

Outcomes

  • Two related journal articles
2 related publications
  1. Fractal Dimension Image Processing for Feature Extraction and Morphological Analysis: Gd3+/13X/DOX/FA MRI Nanocomposite2023 · Journal of Nanomaterials
  2. Magnetic Resonance Imaging Property of Doxorubicin-Loaded Gadolinium/13X Zeolite/Folic Acid Nanocomposite2020 · Journal of Biomedical Physics and Engineering
Completed[Not specified on the current website]

Advanced DTI — Six-Month Clinical Prognosis in ALS

Research question

Evaluation of the relationship between six-month clinical prognosis in patients with ALS and diffusion tensor imaging reports.

Methods & techniques

  • Diffusion tensor imaging
  • Clinical assessment

Role

[Role not specified on the current website.]

Outcomes

  • One related exploratory journal article
1 related publication
  1. Diffusion tensor imaging biomarkers and clinical assessments in amyotrophic lateral sclerosis (ALS) patients: an exploratory study2024 · Annals of Medicine & Surgery
Completed[Not specified on the current website]

Breast Tissue Density Before and After Treatment

Research question

Investigation of changes in breast tissue density in women with breast cancer using digital mammography before and after treatment.

Methods & techniques

  • Digital mammography
  • Breast percent density measurement

Role

[Role not specified on the current website.]

Outcomes

  • One related journal article
1 related publication
  1. Breast percent density changes in digital mammography pre‐ and post‐radiotherapy2024 · Journal of Medical Radiation Sciences
Completed[Not specified on the current website]

Brain Perfusion Measurement Software

Research question

Design and implementation of software for measurement of brain perfusion using an optimized model.

Methods & techniques

  • Brain perfusion measurement
  • Optimized modeling
  • Software implementation

Role

[Role not specified on the current website.]

Outcomes

  • [Software]